Angiogenesis in atherogenesis.

نویسندگان

  • Joerg Herrmann
  • Lilach O Lerman
  • Debabrata Mukhopadhyay
  • Claudio Napoli
  • Amir Lerman
چکیده

Atherogenesis is the pathobiological process, which underlies atherosclerotic cardiovascular disease and evolves in the 3 stages of initiation, progression, and complication to clinical significance. Of note, this process is associated with neovascularization, and it was not until recently that the implications of angiogenesis in atherogenesis were delineated. This article gives an updated overview on this topic and briefly reflects on the similarities with neovessel formation in carcinogenesis.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hypoxia, Angiogenesis and Atherogenesis

The balance between vascular oxygen supply and metabolic demand for oxygen within the vasculature is normally tightly regulated. An imbalance leads to hypoxia and a consequential cascade of cellular signals that attempt to offset the effects of hypoxia. Hypoxia is invariably associated with atherosclerosis, wound repair, inflammation and vascular disease. The anoxaemia hypothesis proposes that ...

متن کامل

The Vascular Biology of Atherosclerosis

THE EVOLUTION OF ATHEROMA. . . . . . . . 1000 Smooth Muscle Cell Migration and Proliferation . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1000 Smooth Muscle Cell Death During Atherogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . 1000 The Arterial Extracellular Matrix. . . . . . 1001 Angiogenesis in Plaques. . . . . . . . . . . . . . . 1001 Plaque Mineralization. . . . . ....

متن کامل

Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR) -dependent signaling.

Angiogenesis and vascular cell proliferation are pivotal in physiological and pathological processes including atherogenesis, restenosis, wound healing, and cancer development. Here we show that mammalian target of rapamycin (mTOR) signaling plays a key role in hypoxia-triggered smooth muscle and endothelial proliferation and angiogenesis in vitro. Hypoxia significantly increased DNA synthesis ...

متن کامل

Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro.

Nicotine is a major component of cigarette smoke and has been postulated to play an important role in atherogenesis and malignancy. Endothelial cell growth may be regulated by nicotine, yet operative mechanisms at the endothelial level are poorly understood. We studied the effects of nicotine (10(-14)-10(-4) M) on endothelial DNA synthesis, DNA repair, proliferation, and cytotoxicity by using c...

متن کامل

Cytoplasmic expression and extracellular deposition of an antiangiogenic factor, pigment epithelium-derived factor, in human atherosclerotic plaques.

OBJECTIVE To assess the expression and distribution of a neurotrophic/antiangiogenic factor, pigment epithelium-derived factor (PEDF), related to angiogenesis that is a possibly key event during atherogenesis in human atherosclerotic plaques. METHODS AND RESULTS Twenty fresh aortic samples were used for reverse-transcription polymerase chain reaction (RT-PCR), Western blot, and immunohistoche...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Arteriosclerosis, thrombosis, and vascular biology

دوره 26 9  شماره 

صفحات  -

تاریخ انتشار 2006